Hunting the Inheritance of Huntington’s Disease MiniLab
Understanding Mendelian genetics & constructing pedigree
- Study Mendelian genetics by using a real-life example of the inheritance of Huntington’s Disease (an autosomal dominant genetic disease)
- Students form groups to construct a family pedigree and use the pedigree to observe disease patterns and make predictions about the inheritance of HD
- To develop an understanding of gel electrophoresis to confirm predictions & explain patterns observed using scientific data
- Extension activities: role play as genetic counselors, debate on genetic testing, construct a standard curve to find out the gene fragment sizes
Difficulty Level: 
SKU: M3010<
Lab techniques covered: Pipetting, Gel Electrophoresis
Major HKDSE-related chapters: Carrier of Genetic information – DNA, Mendelian Inheritance, Human Inheritance (Pedigree), DNA fingerprinting, PCR
Teacher and Student Guide downloads:
Materials included:
- Pedigree Frame & name cards
- 5 DNA samples
- GreenGel Cups
- Running buffer
- Pipette tips
- Microcentrifuge tubes
